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If hematological toxicities do not recover within 4 weeks, refer the patient to a hematologist for further investigations including bone marrow analysis and blood sample for cytogenetics. Preclinical studies have demonstrated that TALZENNA blocks PARP enzyme activity and traps PARP at the site of DNA damage, leading to decreased cancer cell death. Important Safety InformationXTANDI (enzalutamide) is an oral poly ADP-ribose polymerase (PARP), which plays a role in DNA damage repair.

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